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7.91J

Foundations of Computational and Systems Biology

Prof. Christopher Burge, Prof. David Gifford, Prof. Ernest Fraenkel | Spring 2014

Science & Math Biology Engineering Biological Engineering Systems Engineering Computation and Systems Biology Computational Biology Computational Modeling and Simulation

前往原始課程

CC BY-NC-SA 4.0

課程簡介

This course is an introduction to computational biology emphasizing the fundamentals of nucleic acid and protein sequence and structural analysis; it also includes an introduction to the analysis of complex biological systems. Topics covered in the course include principles and methods used for sequence alignment, motif finding, structural modeling, structure prediction and network modeling, as well as currently emerging research areas.

Course Information

Source	MIT 開放式課程
科系	Biological Engineering
Language	English
影片數	22

課程影片 (22)

1. Introduction to Computational and Systems Biology

1. Introduction to Computational and Systems Biology

2. Local Alignment (BLAST) and Statistics

2. Local Alignment (BLAST) and Statistics

3. Global Alignment of Protein Sequences (NW, SW, PAM, BLOSUM)

3. Global Alignment of Protein Sequences (NW, SW, PAM, BLOSUM)

4. Comparative Genomic Analysis of Gene Regulation

4. Comparative Genomic Analysis of Gene Regulation

5. Library Complexity and Short Read Alignment (Mapping)

5. Library Complexity and Short Read Alignment (Mapping)

6. Genome Assembly

6. Genome Assembly

7. ChIP-seq Analysis; DNA-protein Interactions

7. ChIP-seq Analysis; DNA-protein Interactions

8. RNA-sequence Analysis: Expression, Isoforms

8. RNA-sequence Analysis: Expression, Isoforms

9. Modeling and Discovery of Sequence Motifs

9. Modeling and Discovery of Sequence Motifs

10. Markov and Hidden Markov Models of Genomic and Protein Features

10. Markov and Hidden Markov Models of Genomic and Protein Features

11. RNA Secondary Structure; Biological Functions and Predictions

11. RNA Secondary Structure; Biological Functions and Predictions

12. Introduction to Protein Structure; Structure Comparison and Classification

12. Introduction to Protein Structure; Structure Comparison and Classification

13. Predicting Protein Structure

13. Predicting Protein Structure

14. Predicting Protein Interactions

14. Predicting Protein Interactions

15. Gene Regulatory Networks

15. Gene Regulatory Networks

16. Protein Interaction Networks

16. Protein Interaction Networks

17. Logic Modeling of Cell Signaling Networks

17. Logic Modeling of Cell Signaling Networks

18. Analysis of Chromatin Structure

18. Analysis of Chromatin Structure

19. Discovering Quantitative Trait Loci (QTLs)

19. Discovering Quantitative Trait Loci (QTLs)

20. Human Genetics, SNPs, and Genome Wide Associate Studies

20. Human Genetics, SNPs, and Genome Wide Associate Studies

21. Synthetic Biology: From Parts to Modules to Therapeutic Systems

21. Synthetic Biology: From Parts to Modules to Therapeutic Systems

22. Causality, Natural Computing, and Engineering Genomes

22. Causality, Natural Computing, and Engineering Genomes